解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Bioassay directed fractionation of the (1:1) chloroform-methanol extract of Gentiana spathacea H.B.K (Gentianaceae) led to the isolation of gentiopicroside (gentiopricrin) (1), the major spasmolytic component of the plant. Gentiopicroside inhibited, in a concentration-dependent manner, the spontaneous contractions of ...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2000-9774
更新日期:2000-12-01 00:00:00
abstract::Three new coumarin derivatives, compounds 1-3, three new furanocoumarins, compounds 4-6, and a novel dioxocane derivative, compound 7, were isolated from the fern Cyclosorus interruptus (Willd.) H. Itô. Based on spectrometric and spectroscopic analysis (FAB or El mass spectrometry as well as 1D and 2D NMR experiments)...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2000-9908
更新日期:2000-12-01 00:00:00
abstract::The essential oil obtained from the aerial parts of Phlomis lanata has been analyzed by GC/MS. 48 compounds representing 96.85% of the oil were identified; alpha-pinene, limonene and trans-caryophyllene were found as its main components. The essential all showed a moderate in vitro activity against six Gram (+/-) bact...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2000-8631
更新日期:2000-10-01 00:00:00
abstract::The inhibitory activity of stilbenes isolated from medicinal plants on cell adhesion molecules on the surface of THP-1 human monocytic cell lines was investigated. Among ten stilbenes tested, four stilbenes displayed a significant inhibitory activity on the expression of both intercellular adhesion molecule-1 (ICAM-1)...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2000-8634
更新日期:2000-10-01 00:00:00
abstract::Investigation of Podachaenium eminens afforded nine sesquiterpene lactones (Sls) from which costunolide, 7-hydroxycostunolide, santamarin as well as 3-chlorodehydroleucodin are new for this plant and 3,4-dehydro-4-dehydroxypodachaenin (= 3-costoyloxydehydroleucodin) is found for the first time in nature. All isolated ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2000-8649
更新日期:2000-10-01 00:00:00
abstract::Nine isoflavonoids including a new pterocarpene, puemiricarpene, were isolated from the tuberous root of Pueraria mirifica (Leguminosae). The structure of puemiricarpene was determined by spectroscopic means. Estrogenic activity of the isolated isoflavonoids was tested using MCF-7 human breast cancer cells. Moderate a...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2000-8603
更新日期:2000-08-01 00:00:00
abstract::From stem barks of Isolona guesquiereina three known bisbenzylisoquinolines were isolated and identified as (-)-curine, chondrofoline and isochondodendrine. Structures were established mainly on the basis of comparison of their physical and spectral data with published data for them and their methylated derivatives. C...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2000-8610
更新日期:2000-08-01 00:00:00
abstract::Nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) are the major mediators produced in activated macrophages which contribute to the circulatory failure associated with septic shock. An activity-guided fractionation of an MeOH extract of stem bark of Magnolia obovata afforded two inhibitors of NO production...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2000-8592
更新日期:2000-06-01 00:00:00
abstract::Infusions of Citrullus colocynthis Schrad. (Cucurbitaceae) fruits are traditionally used as antidiabetic medication in Mediterranean countries, but to our knowledge no studies have been undertaken so far to determine the possible mechanisms involved in the antidiabetic properties of the fruit. The present study was de...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2000-8586
更新日期:2000-06-01 00:00:00
abstract::A simple and efficient method for the separation of the three phenolic diketones, curcumin 1, demethoxycurcumin 2, and bis-demethoxycurcumin 3, isolated from the rhizomes of Curcuma longa has been developed. The method is of general applicability for the separation of compounds containing acidic and chelating groups a...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2000-8533
更新日期:2000-05-01 00:00:00
abstract::Bioactivity-directed separation led to the identification of four compounds, viz. denbinobin (1), 3,7-dihydroxy-2,4-dimethoxyphenanthrene (2), 3-methylgigantol (3), and erianthridin (4) from the ethanolic extract of Ephemerantha lonchophylla. Antiplatelet tests were carried out using 4 different aggregation inducers, ...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2000-8553
更新日期:2000-05-01 00:00:00
abstract::A series of mainly marine derived natural products were tested for their activities against Mycobacterium tuberculosis and M. avium. Of the thirty-nine compounds tested fifteen demonstrated minimum inhibition concentrations (MICs) of 32 micrograms/ml or less, and eleven had MICs of 16 micrograms/ml or less. The most a...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2000-8534
更新日期:2000-05-01 00:00:00
abstract::Aquaticol, an unusual bis-sesquiterpene was isolated from the medicinal plant Veronica anagallis-aquatica, in addition to 11 known compounds, aucubin, geniposidic acid, mussaenoside, catalposide, verproside, amphicoside, catalpol, boschnaloside, shanzhiside methyl ester, sitosterol and beta-stigmast-4-en-6 beta-ol-3-o...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2000-8564
更新日期:2000-04-01 00:00:00
abstract::This study demonstrated that plant extracts containing acetylenic isobutylamides and polyacetylenes, previously reported as occurring in Echinacea, have phototoxic antimicrobial activity against fungi, including clinically relevant pathogenic fungi. Results show that hexane extracts of Echinacea variably inhibit growt...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2000-8573
更新日期:2000-04-01 00:00:00
abstract::Three new glycosides, 1,4,8-trihydroxynaphthalene-1-O-D-glucopyranosyl-(1-->6)-beta-D- xylopyranoside (1), 1,4,8-trihydroxynaphthalene-1-O-beta-D-glucopyranosyl-(1-->6)-alph a-L- arabinopyranoside (2), 1-hydroxy-4-methoxynaphthalene-1-O-beta-D-glucopyranosyl-(1-->6)- alpha-L-rhamnopyranoside (3), were isolated from th...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-0029-1243129
更新日期:2000-03-01 00:00:00
abstract::Aloe barbadensis polysaccharide was partially digested with cellulase and further purified by dialysis, stepwise ethanol precipitation, and size exclusion chromatography. Crude modified Aloe polysaccharide (MAP) activated macrophage cells and stimulated fibroblast growth. Under the same conditions, native Aloe barbade...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2000-11125
更新日期:2000-03-01 00:00:00
abstract::The 2-mono- and 2,13-bis-glutathionyl adducts of helenalin and the 2-monoglutathionyl adduct of 11 alpha,13-dihydrohelenalin acetate were previously shown to be formed by spontaneous Michael addition at physiological pH. In living cells, glutathione (GSH) conjugation of many types of electrophilic agents is catalysed ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2000-11123
更新日期:2000-03-01 00:00:00
abstract::The tertiary and quaternary alkaloids isolated from the stem bark, root bark and seeds of Peschiera fuchsiaefolia are reported. The tertiary alkaloid crude extract from the stem bark was tested in vitro against Plasmodium falciparum on the basis of the antimalarial use of the plant. It showed good activity against bot...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-0029-1243122
更新日期:2000-02-01 00:00:00
abstract::Aerial parts of Persicaria lapathifolia S.F. Gray (Polygonaceae) exhibited an inhibitory effect on superoxide production in unopsonized zymosan-stimulated human monocytes. Two known compounds, quercetin 3-O-beta-(2"-galloyl)-glucopyranoside and quercetin 3-O-beta-(2"-galloyl)-rhamnopyranoside, and a new compound, quer...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-0029-1243112
更新日期:2000-02-01 00:00:00
abstract::The roots of Cryptolepis sanguinolenta have been investigated for their chemical composition since 1931 but so far no studies on the leaves have been reported although they are used in traditional medicine in Guinea-Bissau. Two new alkaloids identified as cryptolepinoic acid (1) and methyl cryptolepinoate (2) and the ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2000-11106
更新日期:2000-02-01 00:00:00
abstract::The chemical composition of the three essential oils obtained by steam distillation of the mastic gum, leaves and twigs of Pistacia lentiscus var. chia, was studied by GC/MS. Sixty nine constituents were identified from the oils. alpha-Pinene, myrcene, trans-caryophyllene and germacrene D were found to be the major co...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-960856
更新日期:1999-12-01 00:00:00
abstract::Based on the inhibition of Cu(2+)-induced LDL oxidation as marker, the major antioxidants in the fruits of Forsythia suspensa and the stems of Magnolia coco were identified. Of these bioactive tetrahydrofurofuran lignans, pinoresinol, phillygenin, and syringaresinol were more potent than probucol. Sesamin and fargesin...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-1999-14093
更新日期:1999-12-01 00:00:00
abstract::Two new beta-carboline alkaloids, hedyocapitelline and hedyocapitine, were isolated from Hedyotis capitellata var. mollis (Rubiaceae). Their structures were elucidated by spectroscopic data (1)H- and (13)C-NMR, MS, IR, UV). ...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-960861
更新日期:1999-12-01 00:00:00
abstract::The activity-guided fractionation of the extract of the root of Salvia miltiorrhiza B. (Labiatae, Tanshen), led to the isolation of four active components responsible for the anti-allergic activity in vitro. Among them, 15,16-dihydrotanshinone-I and cryptotanshinone demonstrated significant inhibition of the release o...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-960839
更新日期:1999-10-01 00:00:00
abstract::A new steroidal saponin, timosaponin F, along with six known compounds was isolated from the rhizomes of Anemarrhena asphodeloides Bge. On the basis of chemical and spectroscopic evidence, the structure of timosaponin F was elucidated as (5beta, 25 S):-spirostan-3beta,15alpha,23alpha-triol-3-O-beta- glucopyranosyl-(1-...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-960842
更新日期:1999-10-01 00:00:00
abstract::Three new tetrahydroprotoberberine N-oxide alkaloids, (-)- cis-corydalmine N-oxide, (-)- trans-corydalmine N-oxide, and (-)- trans-isocorypalmine N-oxide, along with three known benzo[ C]phenanthridine alkaloids, norsanguinarine, dihydrosanguinarine, and oxysanguinarine, six known berberine alkaloids, (-)-tetrahydropa...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-1999-14090
更新日期:1999-10-01 00:00:00
abstract::A novel experimental model of free radical-induced emesis for screening anti-emetic compounds from natural sources was established. 2,2'-Azobis(2-amidinopropane) dihydrochloride (AAPH) dissolved in liposome induced emesis in young chickens, and the emesis was prevented by antioxidants including N-(2-mercaptopropionyl)...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-960829
更新日期:1999-08-01 00:00:00
abstract::The hydroalcoholic extract (HE) obtained from stems and leaves of Hedyosmum brasiliense, given i.p., produced significant inhibition of acetic acid-induced abdominal constriction in mice, with a mean ID50 of 12.7 mg/kg. This effect installed rapidly (0.5 h) and lasted for up to 2 h. Given orally up to 1000 mg/kg, the ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-1999-14007
更新日期:1999-08-01 00:00:00
abstract::Electrospray ionization mass spectrometry (ESI-MS) combined with multiple tandem mass spectrometry (MS (n)) has been applied for simultaneously determining lipo-alkaloids from the aconite tubers. ESI-MS can give a very good mass separation for lipo-alkaloid mixture and MS (n) can provide structural information. Accord...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-1999-14086
更新日期:1999-06-01 00:00:00
abstract::The inhibitory effect of flavonoids and phenolic acids, which could be transformed from flavonoids by human intestinal microflora, on the growth of Helicobacter pylori (HP) was investigated. Ponciretin, hesperetin, naringenin and diosmetin were active against HP. Among them, ponciretin was the most potent and its MIC ...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-960805
更新日期:1999-06-01 00:00:00
abstract::Ginkgetin, a biflavone isolated from Ginkgo biloba leaves, was previously reported as an inhibitor of group II phospholipase A2. In this study, ginkgetin was evaluated for in vivo antiarthritic and analgesic activities. Ginkgetin (10-20 mg/kg/day) strongly reduced arthritic inflammation in an animal model of rat adjuv...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-960815
更新日期:1999-06-01 00:00:00
abstract::A methanolic extract of Commelina communis showed potent inhibitory activity against alpha-glucosidase. One pyrrolidine alkaloid, 2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine (DMDP, 1) and four piperidine alkaloids, 1-deoxymannojirimycin (2), 1-deoxynojirimycin (3), alpha-homonojirimycin (4) and 7-O-beta-D-glucopyrano...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-960803
更新日期:1999-06-01 00:00:00
abstract::Activator protein 1 (AP-1) is a transcription factor which plays a critical role in inflammation and carcinogenesis. The present study was conducted to investigate the effect of berberine, an isoquinoline alkaloid present in plants of the genera Berberis and Coptis, on the activity of AP-1 using a reporter gene assay ...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-960795
更新日期:1999-05-01 00:00:00
abstract::The active ingredient dl-tetrahydropalmatine (THP) isolated from the traditional Chinese herb Corydalis racemosa has been found to have antihypertensive effects. However, severe cardiac and neurological toxic effects were reported from using this herb for the treatment of pain. In an isolated perfused rat heart model,...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-1999-13998
更新日期:1999-05-01 00:00:00
abstract::In the present study, we attempted to compare quercetin methyl ethers and to look for the structure-activity relationships, which may be helpful for synthesizing more active compounds for the treatment of asthma. Four present and two previously studied quercetin methyl ethers concentration-dependently relaxed histamin...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-960776
更新日期:1999-04-01 00:00:00
abstract::Positive inotropic effects induced by 6-benzylaminopurine (6-BAP), kinetin and zeatin were studied in rat atria. The potency order observed was 6-BAP > or = kinetin > zeatin. Suramin, a P2-purinoceptor antagonist, inhibited the positive effect of 6-BAP suggesting the involvement of P2-purinoceptors in the positive eff...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-1999-13987
更新日期:1999-04-01 00:00:00
abstract::The composition and the antimicrobial activity of the essential oil from the leaves of Peumus boldus is investigated. Analyses of the oil obtained by hydrodistillation were carried out by GC and GC-MS using columns of two different stationary phases. Fractionation of the essential oil by column chromatography on silic...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-960461
更新日期:1999-03-01 00:00:00
abstract::According to traditional usage, the extract of Longan Arillus was tested for its anxiolytic-like effect by application of the Vogel-type anti-conflict method in mice. The extract indicated significant activity at a dose of 2 g/kg, s.c., and results of the bioassay-oriented isolation revealed adenosine to be the active...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-1999-14055
更新日期:1999-03-01 00:00:00
abstract::PAPAVER SOMNIFERUM L. tissue cultures, issued from various explants (cotyledons, hypocotyls, roots) derived from plantlets belonging to two genotypes, were established on LS solid medium containing growth regulators (NAA, Kin) in various combinations. Hypocotyls and roots were found to be interesting explants to obtai...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-960457
更新日期:1999-03-01 00:00:00
abstract::The in vitro antiprotozoal activity of 18 natural flavonoids has been determined against Entamoeba histolytica and Giardia lamblia. (-)-Epicatechin, (-)-epigallocatechin and kaempferol were the most active flavonoids against both protozoa. ...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-960445
更新日期:1999-02-01 00:00:00